Chewable soft gelatin-encapsulated pharmaceutical adsorbates

Details Chewable soft gelatin-encapsulated pharmaceutical adsorbates Chewable soft gelatin-encapsulated pharmaceutical adsorbates

1998-04-22

2000-02-22

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424456, 424683, 514962, 514974, A61K 948

Patent

active

060277467

ABSTRACT:
The present invention relates to novel liquid oral suspensions incorporated within a soft gelatin capsule comprised of a bitter or bad-tasting pharmaceutical active (such as antihistamines, decongestants and the like) which is dispersed within an adsorbate comprised of magnesium trisilicate, silicon dioxide or mixture thereof. The adsorbate is dispersed within an aqueous or non-aqueous carrier base and combined with other flavors, sweeteners, emulsifiers and the like. The adsorbate not only taste-masks the active but also insures that is evenly dispersed through the liquid suspension so that a uniform dosage rate is readily achievable. The encapsulation of the adsorbate within a gelatin capsule makes administration easier for children andmore convenient. The capsule also affords the adsorbate suspension greater shelf life.

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