Chenodeoxycholic acid recovery process

Details Chenodeoxycholic acid recovery process Chenodeoxycholic acid recovery process

1978-08-09

1980-01-29

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 900

Patent

active

041861434

ABSTRACT:
A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions separating the bile acids from the water-soluble constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions; isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxycholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, optionally purifying the chenodeoxycholic acid.
The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.

REFERENCES:
patent: 3919266 (1975-11-01), Saltzman
patent: 3965131 (1976-06-01), Wiele et al.
patent: 4014908 (1977-03-01), Saltzman
patent: 4022806 (1977-05-01), Frost et al.

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