Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-09-29
1983-11-29
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602393P, A61K 31535, C07D49818
Patent
active
044180640
ABSTRACT:
A novel group of maytansinoid compounds has been discovered in the seed tissue of Trewia nudiflora. They are represented by the general formula ##STR1## and are uniquely characterized by a 12-membered ring joining C-3 and the amide nitrogen at C-18, and also by a distinguishing methoxy group on the C-15 carbon. These isolates have proven to be effective in causing the remission of one or more types of malignancies.
REFERENCES:
patent: 4313946 (1982-02-01), Powell et al.
B. Freedman et al., "Biological Activities of Trewia nudiflora Extracts Against Certain Economically Important Insect Pests," J. Chem. Ecol. 8(2): 409-418 (1982).
R. G. Powell et al., "Treflorine, Trenudine, and N-Methyltrenudone: Novel Maytansinoid Tumor Inhibitors Containing Two Fused Macrocyclic Rings," J. Amer. Chem. Soc. 104(18): 4929-4934 (Sep. 8, 1982).
"NCI Reviews Work on Natural Products," in Northern Regional Research Center Notes from the Director, Issue #1405 (Feb. 1, 1980).
"NCI Reviews Work on Natural Products," Northern Regional Research Center Notes from the Director (NRRC Notes), Issue #1405, Feb. 1, 1980.
R. G. Powell et al., "Novel Maytansinoid Tumor Inhibitors from Trewia nudiflora," Abstracts of Papers, Second Chemical Congress of the North American Continent, Aug. 24-29, 1980, Abstract No. 42.
R. G. Powell et al., "Novel Maytansinoid tumor Inhibitors from Trewia nudiflora: Trewiasine, Dehydrotrewiasine, and Demethyltrewiasine," J. Org. Chem. 46: 4398-4403 (Oct. 23, 1981).
R. G. Powell et al., "Treflorine, Trenudine, and N-Methyltrenudone: Novel Maytansinoid Tumor Inhibitors Containing Two Fused Macrocyclic Rings," American Chemical Society, 16th Great Lakes Regional Meeting, Jun. 7-9, 1982, Abstract No. 56.
Chemical Abstracts, vol. 97, Item 107040t (1982) Abstracting Powell et al. in "J. Am. Chem. Soc." (1982), vol. 104, No. 18, pp. 4929-4934.
Chemical Abstracts vol. 96, Item 212490s (1982), Abstracting Freedman et al. in "J. Chem. Ecol." 1982) vol. 8, No. 2, pp. 409-418, (Including Corresponding Chemical Substances Index Reference).
Powell Richard G.
Smith, Jr. Cecil R.
Bond Robert T.
McConnell David G.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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