Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-01-27
1982-02-02
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602393P, A61K 31535, C07D49818
Patent
active
043139469
ABSTRACT:
A novel group of maytansinoid compounds has been discovered in the seed tissue of Trewia nudiflora. They are represented by the general formula ##STR1## and are all characterized by a distinguishing methoxy group on the C-15 carbon. These isolates have proven to be effective in causing the remission of one or more types of malignancies.
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M. C. Wani et al., J.C.S. Chem. Commun., p. 390 (1973).
S. M. Kupchan et al., J. Org. Chem. 42: 2349-2357 (1977).
S. M. Kupchan et al., J. Med. Chem. 21: 31-37 (1978).
E. Higashide et al., Nature 270: 721-722 (1977).
M. Asai et al., Tetrahedron 35: 1079-1085 (1979).
A. G. Galsky et al., Plant Physiol. 65: 184-185 (1980).
Powell Richard G.
Smith, Jr. Cecil R.
Bond Robert T.
McConnell David G.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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