Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-01-22
1998-02-24
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514339, 548423, 5462767, C07C48704, A61K 3140
Patent
active
057212678
ABSTRACT:
Compounds represented by the Formula I: ##STR1## wherein: R.sup.1 is hydrogen or lower alkyl;
REFERENCES:
patent: 4912107 (1990-03-01), Kleinschroth et al.
patent: 4999369 (1991-03-01), Bair
patent: 5057614 (1991-10-01), Davis et al.
patent: 5166204 (1992-11-01), Nagai et al.
Toullec et al., "The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C", J. Biol. Chem., 266(24), 15771-15781 (1991).
Bit et al., "Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformatiion restriction", J. Med. Chem., 36, 21-29 (1993).
Davis et al., "Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides",J. Med. Chem., 35, 177-184 (1992).
Davis et al., "A mild conversion of maleic anhydrides into maleimides", Tetrahedron Lett., 31(36), 5201-5204 (1990).
Davis et al., "A convenient synthesis of bisindolyl-and indolylaryl-maleic anhydrides", Tetrahedron Lett., 31(16), 2353-2356 (1990).
Davis et al., "Potent selective inhibitors of protein kinase C", FEBS Lett., 259(1), 61-63 (1989).
Eenkhorn et al., "The Wittig reaction of indole-2-methyltriphenylphosphonium iodide . . . ", Can. J. Chem., 51(5), 792-810 (1973).
Schroder et al., Arzneimittelchemie I, Georg Theime Verlag, Stuttgart, Germany, 1976, pp. 24-38 cited.
Eitel et al., "New regio-and stereo-controlled reactions of 2-vinylindoles Abstracts, 111(9), 77796g (1989).
Winograd, B. Oxford Textbook of Oncology, vol. 1, ed. by Peckham, M. et al. (Oxford University Press, Oxford), p. 486 (1995).
Cleton, F.J. Oxford Textbook of Oncology, vol. 1, ed. by Peckham, M. et al. (Oxford University Press, Oxford), pp. 445-453 (1995).
Workman, P. et al. Oxford Textbook of Oncology, vol. 1, ed. by Peckham, M. et al. (Oxford University Press, Oxford), p. 506 (1995).
Crilley, P.A. et al. Basic Pharmacology in Medicine, ed. by Dipalma, J.R. et al. (Medical Surveillance Inc., West Chester), pp. 659-661(1994).
Mayer, R.J. Harrison's Principles of Internal Medicine, vol. 2, ed. by Isselbacher, K.J. et al. (McGraw-Hill, N.Y.), pp. 1382-1386 and 1532-1535(1994).
Hochberg, F. et al. Harrison's Principles of Internal Medicine, vol. 2, ed. by Isselbacher, K.J. et al. (McGraw-Hill, N.Y.), pp. 2256-2269 (1994).
Colucci, W.S. et al. Harrison's Principles of Internal Medicine, vol. 1, ed. by Isselbacher, K.J. et al. (McGraw-Hill, N.Y.), pp. 1101-1105 (1994).
Blobe, G.C. et al. Cancer and Metastasis Reviews, vol. 13, p. 411, the abstract only (1994).
Shah Mukund J.
Syntex (U.S.A.) Inc.
Wong King Lit
LandOfFree
Chemotherapeutic pyrrolocarbazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chemotherapeutic pyrrolocarbazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemotherapeutic pyrrolocarbazole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1875589