Chemotherapeutic microemulsion compositions of paclitaxel...

Details Chemotherapeutic microemulsion compositions of paclitaxel... Chemotherapeutic microemulsion compositions of paclitaxel...

2006-10-03

2006-10-03

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S405000, C424S422000

Reexamination Certificate

active

07115565

ABSTRACT:
Pharmaceutical compositions suitable for oral administration comprising paclitaxel, a solvent, a surfactant, a substituted cellulosic polymer, and optionally but preferably a P-glycoprotein inhibitor. The composition may further comprise a diglyceride or mixture of diglyceride and monoglyceride. The composition generates a supersaturated paclitaxel microemulsion upon contact with water resulting in improved oral bioavailability of paclitaxel.

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