Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-10-15
1995-04-11
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514301, 546114, 548464, 548466, A61K 3140, C07D40304
Patent
active
054058643
ABSTRACT:
Maleimide derivatives, i.e., the compounds of Formula I: ##STR1## wherein: R.sup.1 is H, halo, alkyl, OH, alkoxy, haloalkyl, NO.sub.2, or NR.sup.5 R.sup.6 ;
REFERENCES:
patent: 5057614 (1991-10-01), Davis et al.
Toullec, et al., "The Bisindolylmaleimide GF 109203X is a Potent and Selective Inhibitor of Protein Kinase C*", J. Bio. Chem., vol. 266, No. 24, pp. 15771-15781, 1991.
Bit, et al., "Inhibitors of Protein Kinase C. 3. Potent and Highly Selective Bisindolylmaleimides by Conformational Restriction", J. Med. Chem. 1993, 36 21-29.
Davis, et al., "Inhibitors of Protein Kinase C. 1..sup.1 2,3-Bisarylmaleimides", J. Med. Chem. 1992, 35, 177-184.
Davis, et al.,, "A Mild Conversion of Maleic Anhydrides Into Maleimides", Tetrahedron Letters, vol. 31, No. 36, pp. 5201-5204, 1990.
Davis, et al., "A Convenient Synthesis of Bisindolyl-and Indolylaryl-Maleic Anhydrides", Tetrahedron Letters, vol. 31, No. 16, pp. 2353-2356, 1990.
Davis, et al., "Potent selective inhibitors of protein kinase C", Febs Letters, vol. 259, No. 1, 61-63, Dec. 1989.
Haley Jacqueline
Krubiner Alan M.
Lee Mary C.
Lowin David A.
Syntex (U.S.A.) Inc.
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