Chemotactic wound healing peptides

Details Chemotactic wound healing peptides Chemotactic wound healing peptides

1995-06-01

1998-10-20

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 17, 530324, 530326, 530329, A61K 3800, A61K 3804, C07K 500, C07K 700

Patent

active

058246479

ABSTRACT:
Peptides corresponding to amino acid sequences in the C-terminal region of TGF-.beta. are provided. The peptides all contain at least a seven amino acid sequence substantially corresponding to the amino acid sequence of TGF-.beta.1 amino acids 368-374: VYYVGRK, as well as homologs and analogs thereof. The peptides have chemotactic activity towards fibroblasts, monocytes and neutrophils and induce fibroblast proliferation and collagen synthesis. The peptides may be used in compositions and methods for promoting wound healing.

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