Chemotactic, antibiotic and lipopolysaccharide-binding peptide f

Details Chemotactic, antibiotic and lipopolysaccharide-binding peptide f Chemotactic, antibiotic and lipopolysaccharide-binding peptide f

1992-03-19

1996-01-16

Furman, Keith C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530328, C07K 706, C07K 14435, C07K 1452

Patent

active

054848857

ABSTRACT:
Disclosed is a homogeneously pure monocyte chemotactic protein, CAP37, and the entire coding sequences for unprocessed and mature human CAP37 protein. Further, the recombinant production, from nucleic acid coding sequences, of mature CAP37 protein and the mature protein with amino-terminal and/or carboxy-terminal extensions is described. Also disclosed are methods to identify and recombinantly produce bioactive peptides derived from the CAP37 protein coding sequence which are effective chemoattractants of monocytes and/or are capable of binding bacterial lipopolysaccharide. A method of preparing homogeneously pure CAP37 using hydrophobic HPLC is described. Bioactive peptide fragments of CAP37 having chemotactic, antibacterial and/or LPS-binding activity are disclosed. Finally, methods of treating wounds, diseased tissue, such as tumors, and infections are described.

REFERENCES:
patent: 4427660 (1984-01-01), Schiffman et al.
patent: 5087569 (1992-02-01), Gabay et al.
patent: 5162499 (1992-11-01), Trampota et al.
Meyer-Ingold, 1993. Tibtech, 11:387-392.
Abstract WPI Accesion No. 93-320680/40 of WO 9319087.

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