Chemorepellant compound

Details Chemorepellant compound Chemorepellant compound

1986-06-30

1988-04-12

Lusignan, Michael R.

Stock material or miscellaneous articles

Composite

2604109R, 260413, 427 2, 435134, A01N 102, B32B 904, C11C 302, C12P 764

Patent

active

047374136

ABSTRACT:
A chemorepellant compound is disclosed having a general formula ##STR1## where R.sub.1 is H or an alkyl group in the range C.sub.1 to C.sub.6, and R.sub.2 is H or an appropriate hydroxyl protecting group, and pharmaceutically acceptable salts and esters thereof. A preferred form of the compound where R.sub.1 is hydrogen and R.sub.2 is hydrogen is made by incubating linoleic acid with soyabean lipoxygenase or with cytosol associated endothelial cell derived lipoxygenase. The chemorepellant compound can be bound to a prosthetic surface via an intermediate linking species such as a protein and studies have shown that platelet adhesion onto in the vicinity of a thrombogenic surface is greatly reduced in comparison to non-chemorepellant coated surfaces.

REFERENCES:
W. H. Tallent et al., "(R)-13-hydro-xy-cis-9, trans-11-octadeca dienoie acid, the Principal Fatty Acid from Coriaria napaleusis Seed Oil", Nov. 21, 1966, Chemical Abstracts, vol. 65, No. 11.
M. O. Funk et al., "The Preparation and Characterization of the Methoxy Derivatives of Polyunsaturated Fatty Acids; Stabilized Product Analogs of Lipoxygenase Catalysis", May 11, 1981, Chemical Abstracts, vol. 94, No. 19.
K. L. Mikolajczak et al., "Effect of Oat Constituents on Aggregation Behavior of Oryzaephilus Surinamensis", Jan. 31, 1983, Chemical Abstracts, vol. 98, No. 5.

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