Chemoprevention of metachronous adenomatous colorectal polyps

Details Chemoprevention of metachronous adenomatous colorectal polyps Chemoprevention of metachronous adenomatous colorectal polyps

1996-09-23

1998-09-29

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3156

Patent

active

058146253

ABSTRACT:
A method for protecting a colorectum against a recurrence of adenomas is provided, wherein ursodeoxycholic acid or an amide-conjugate thereof, or ursodeoxycholic acid or an amide-conjugate thereof in combination with sulindac or a phenolic NSAID is administered to a patient afflicted with colorectal adenomas in an amount effective to prevent the recurrence of colorectal adenomas following the removal thereof.

REFERENCES:
Bussey, H.J.R., "Familial Polyposis Coli : Family Studies, Histopathology, Differential Diagnosis, and Results of Treatment", Johns Hopkins University Press, Baltimore, MD (1975).
"Sulindac", Physician's Desk Reference, Medical Economics Data, Montvale, NJ, 1483-1486, (1993).
I. Ahnfeldt-Rhonne, et al., "Clinical Evidence Supporting the Radical Scavenger Mechanism of 5-Aminosalicyclic Acid", Gastroenterology, 98, 1162-1169, (1990).
I. Ahnfeldt-Rhonne, "Rationales for Drug Development in Inflammation: Eicosanoids and Oxygen-derived Free Radicals", Danish Med. Bull., 38, 291-303, (1991).
H. Allgayer, et al., "Is Radical Scavenging Necessary in the Treatment of Inflammatory Bowel Disease", Gastroenterology, 100, 581-582, (1991).
H. Allgayer, et al., "Superoxide, Hydroxyl and Fatty Acid Radical Scavenging by Aminosalicylated", Biochem. Pharm., 43, 259-262, (1992).
H. Allgayer, et al., "Superoxide Inhibiton Following Different Stimuli of Respitory Burst and Metabolism of Aminosalicylate in Neutrophils", Dig. Dis. & Sci., 39, 145-151, (1994).
W. H. Bachrach, et al., "Ursodeoxycholic Acid in the Treatment of Cholesterol Cholelithiasis", Dig. Dis. Sci., 27, 833-856, (1982).
B. I. Cohen, et al., "The Role of Bile Acids in Colorectal Carcinogenesis", In: Colorectal Cancer: From Pathogenesis to Prevention?, Seitz HK et al., eds., New York, Springer-Verig., 125-138, (1989).
P. Czygan, et al., "Chenodeoxycholic Acid But Not Ursodeoxycholic Acid Enhances Colonic Carcinogenesis in the Rat", Bile Acids and Cholesterol in Health and Disease, Ed. Paumgartner et al., MTP Press Limited, Lancaster, England, 393-395, (1983).
T. C. Dinis, et al., "Action of Phenolic Derivatives (Acetominophen, Salicylate, and 5-aminosalicylate) as Inhibitors of Membrane Lipid Peroxidation and as Peroxyl Radical Scavengers", Arch. Bioc. Biop., 315, 161-169, (1994).
D. E. Duggan, et al., "The Disposition of Sulindac", Clin. Pharmacol. Ther., 21, 326-335, (1977).
E. R. Fearon, et al., "Clonal Analysis of Human Colorectal Tumors", Science, 238, 193, (1987).
A. Fisher-Nielsen, et al., "8-Hydroxydeoxyguanosine in vitro: Effects of Glutathione, Ascorbate,and 5-Aminosalicylic Acid", Free Radical Biol. Med., 13, 121-126, (1992).
A. Fischer-Nielsen, et al., "Radiation Induced Formation of 8-hydroxy-2'-deoxyguanosine and Its Prevention by Scavengers"Carcinogenesis, 15, 1609-1612, (1994).
C. Fischer, et al., "Radical-derived Oxidation Products of 5-aminosalicylic Acid and N-acetyl-5-aminosalicylic Acid", J. Chromat. B: Biomed. Appl., 661, 57-68, (1994).
T. S. Gaginella, et al., "Sulfasalazine Multiplicity of Action", Dig. Dis. Sci., 37, 801-812, (1992).
P. Gionchetti, et al., "Scavenger Effect of Sulfasalazine, 5-Aminosalicylic Acid, and Olsalazine on Superoxide Radical Generation", Dig. Dis. Sci., 36, 174-178, (1991).
S. M. Greenfield, et al., "The Effects of 5-aminosalicylic Acid and acetyl-5-aminosalicylic Acid on Lipid Peroxidation in Erthrocytes and Prostaglandin Production by Mononuclear Cells", Aliment. Pharmacol. Ther., 6, 671-683, (1982).
V. Gross, et al., "Free Radicals in Inflammatory Bowel Diseases Pathophysiology and Therapeutic Implications", Hepato-Gastroenterol., 41, 320-327, (1994).
M. J. Hill, "Bile Flow and Colon Cancer", Mutation Review, 238, 313-320, (1990).
M. J. Hill, "From Adenoma to Carcinoma of the Colorectum", Recent Results Cancer Res., 122, 71-84, (1991).
A. F. Hofman, "Chemistry and Enterohepatic Circulation of Bile Acids", Hepatology,, 4s-14s, (1984).
A. F. Hofmann, "Pharmacology of Chenodeoxycholic and Ursodeoxycholic Acid in Man", Bile Acids and Cholesterol in Health and Disease, Ed. Paumgartner, G. et al., MTP Press Limited, Lancaster, England, 301-337, (1983).
H. B. Hucher, et al., "Studies on the Absorbtion, Distribution and Excretion of Indomethacin inVarious Species", J. Pharmacol. Exp. Ther., 153, 237-239, (1996).
S. M. Huijghebaert, et al., "Influence of the Amino Acid Moiety of Deconjugation of Bile Acid Amidates by Cholyglycine Hydrolase of Human Fecal Cultures", J. Lipid Res., 27, 742-752 (1986).
D. Labayle, et al., "Sulindac Causes Regression of Rectal Polyps in Familial Adenomatous Polyposis", Gastroenterology, 101, 635-639, (1991).
A. M. Miles, et al.,"Antioxidant Properties of 5-aminosalicylic Acid: Potential Mechanism for Its Protective Effect in Ulcerative Colitis", Advances in Mucosal Immunology, Part B, Ed. Mestecky et al., Plenum Press, New York, 1317-1321, (1995).
M. Moorghen, et al., "The Protective Effect of Sulindac Against Chemically-induced Primary Colonic Tumors in Mice", J. Pathol., 156, 341-347, (1988).
T. Narisewa, et al., "Inhibtion of Development of Methylnitrosourea-induced Rat Colon Tumors by Indomethacin Treatment", Cancer Research, 41, 1954-1957, (1981).
H. Nava, et al., "Follow-up Colonoscopy in Patients with Colorectal Adenomatous Polyps", Dis. Colon Rectum, 30, 465, (1987).
M. G. Neuman, et al., "Effect of Tauroursodeoxycholic and Ursodeoxycholic Acid on Ethanol-induced Cell Injuries in the Human Hep G2 Cell Line", Gastroenterology, 109, 555-563, (1995).
M. L. Nicholson, et al., "Increased Cell Membrane Arachidonic Acid in Experimental Colorectal Tumors.", Gut, 32, 413-418, (1991).
O. H. Nielsen, et al., "Effect of 5-aminosalicylic Acid and Analogous Substances on Superoxide Generation and Intracellular Free Calcium in Human Neutrophilic Granulocytes", Gastroenterology, 28, 527-532 (1993).
H. W. Olsen, et all, "Review of Recurrent Polyps in Cancer in 500 Patients with Initial Colonoscopy of Polyps", Dig. Colon Rectum, 31, 222-227 (1988).
A. Paganini-Hill, et al., "Aspirin Use in Incidence of Large-bowel Cancer in a California Retirement Community", J. Nat. Cancer Inst., 83, 1182-1183, (1991).
M. Pollard, et al., "The Suppresive Effect of Paroxican on Autochthonous Intestinal Tumors in the Rat", Cancer Letters, 21, 57-61 (1983).
R. E. Poupon, et al., "A Multicenter, Controlled Trial of Ursodiol for the Treatment of Primary Billiary Cirrhosis", N. Eng. J. Med., 324, 1548-1554, (1991).
B. S. Reddy, et al., "Promoting Effect of Bile Acids in Colon Carcinogenesis in Germ-free and Conventional F344 Rats", Cancer Res., 37, 3238-3242, (1977).
J. Rigau, et al., "Effects of Long-term Sulindac Therapy on Colonic Polyposis", Annals of Internal Med., 115, 952-955, (1991).
C. MP. Rodrigues, et al., "Tauroursodeaxycholate Increases Rat Liver Ursodeoxycholate Levels and Limits Lithocholate Formation Better Than Ursodeoxycholate", Gastroenterology, 109, 564-572 (1995).
L. Rosenberg, et al., "A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large Bowel Cancer", J. Nat. Cancer Inst., 83, 355-358, (1991).
A. N. Sarwal, et al., "Effects of Dietary Administration of Chenodeoxycholic Acid on N-Methyl-N-Notrosourea-Induced Colon Cancer in Rats", Bioc. Biophys. Acts, 574, 423-432, (1979).
H. Tamai, et al., "Scavenging Effect of 5-aminosalicylic Acid on Neutrophil-derived Oxidants", Biochem. Pharm., 41, 1001-1006, (1991).
N. Tanida, et al., "Effects of Oral Administration of Sulfolithocholic Acid Disodium Salt and Lithocholid Acid Sodium Salt on N-Methyl-N-Nitrosourea-Induced Colonic Tumorogenesis in Conventional Rats", Cancer Res., 49, 1178-1181, (1989).
M. J. Thun, et al., "Aspirin Use and Reduced Risk of Fatal Colon Cancer", New Eng. J. Med., 323, 1593-1596, (1991).
W. R. Waddell, et al., "Sulindac for Polyposis of the Colon", Am. J. of Surgery, 157, 175-179, (1989).
W. R. Waddel, et al., "Sulindac for Polyposis of the Colon", J. of Surgical Onc., 24, 83-87, (1983).
C. B. Williams, et al., "The St. Marks's Neoplastic Polyp Follow-up Study", Front Gastrointest. Res., 10, 226, (1986).
S. J. Winawer, et al., "Randomized Comparison of Survei

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