Chemolytic EDTA-citric acid composition for dissolution of calcu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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252DIG11, 514557, 514566, 514836, 514891, 128 24A, 128328, A61K 908, A61K 3119, A61K 31195, A61K 31205

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active

048451258

ABSTRACT:
An improved composition for dissolution of renal calculi is disclosed. The composition includes citric acid, preferably at about 10 to about 15% by weight, and an effective amount of a pharmacologically acceptable chelating agent such as EDTA in a sterile aqueous solution having a pH between about 3 and about 4.5. In vivo irrigation with the improved formulation, optionally in combination with incident ultrasound therapy promotes rapid stone dissolution with minimal complications for the patient.

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