Chemokine N-terminal deletion mutations

Details Chemokine N-terminal deletion mutations Chemokine N-terminal deletion mutations

1997-10-23

1998-12-29

Degen, Nancy

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4351721, 4351723, 536 236, C07H 2104, C12N 1519, C12P 2102

Patent

active

058544127

ABSTRACT:
The invention relates to mutant chemokines and pharmaceutical compositions thereof, wherein the mutant inhibits the corresponding endogenous chemokine from binding or activating a responsive receptor. The claimed mutant chemokines can be administered to a patient for the treatment or prophylaxis of a chemokine-mediated disease. The invention further relates to isolated DNAs encoding the mutant chemokines, vectors and recombinant host cells containing the same.

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