Chemokine mutants in the treatment of multiple sclerosis

Details Chemokine mutants in the treatment of multiple sclerosis Chemokine mutants in the treatment of multiple sclerosis

2008-07-22

2008-07-22

Nickol, Gary B. (Department: 1647)

Drug, bio-affecting and body treating compositions

Lymphokine

C435S069500

Reexamination Certificate

active

07402303

ABSTRACT:
Mutants of CC chemokines, which contain at least two mutations in the cationic site of the 40's loop and which, relative to the wild-type molecule, have a reduced GAG-binding activity. In particular it has been found that such mutated chemokines are effective in the treatment of multiple sclerosis and/or demyelinating diseases. A triple mutant of RANTES is the compound showing the best results.

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