Chemokine mutants acting as chemokine antagonists

Details Chemokine mutants acting as chemokine antagonists Chemokine mutants acting as chemokine antagonists

2002-12-16

2009-06-30

Landsman, Robert (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C424S185100, C424S198100

Reexamination Certificate

active

07553483

ABSTRACT:
Mutants of specific CC-chemokines containing a non-conservative substitution in a conserved consensus sequence act as CC-chemokine antagonists, and can be effectively used in the treatment of autoimmune and inflammatory diseases, cancers, and viral or bacterial infections. Particularly preferred are the RANTES/CCL5 mutants having the amino acid sequence of SEQ ID NO: 1, 2, 3, or 4.

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