Chemokine expressed in fetal spleen and its production

Details Chemokine expressed in fetal spleen and its production Chemokine expressed in fetal spleen and its production

1995-06-06

1999-08-31

Mertz, Prema

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

435 695, 435325, 435471, 4352523, 4353201, 435 711, 435 712, 930140, 536 235, C07K 1452, C12N 1519, C12N 1563, C12N 510

Patent

active

059455063

ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (FSEC) from human fetal spleen cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode FSEC, expression vectors for the production of purified FSEC, antibodies capable of binding specifically to FSEC, hybridization probes or oligonucleotides for the detection of FSEC-encoding nucleotide sequences, genetically engineered host cells for the expression of FSEC, diagnostic tests for chemokine activation based on FSEC-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.

REFERENCES:
*Banchereau, J., "Interleukin-4," The Cytokine Handbook, Academic Press, Chapter 6, pp. 120-148 (1991).
*Schall, T. J., "The Chemokines," The Cytokine Handbook, Academic Press, Second Edition, pp. 180-272 (1994).
*Shaw, A. R., "Molecular Biology of Cytokines," The Cytokine Handbook, Academic Press, Chapter 2, pp. 20-46 (1991).
*Vilcek et al., "Immunology of Cytokines," The Cytokine Handbook, Academic Press, Chapter 1, pp. 1-17 (1991).
Nakao et al. (1990) Mol. & Cell. Biol. vol. 10, No. 7, pp. 3646-3658.
Goodman et al. (1992) Biochemistry vol. 31 pp. 10483-10490.

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