Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-04-13
1999-02-23
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 243, 536 2431, 536 2432, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
058742115
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel chemokine (EEC) expressed in human eosinophil cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode EEC, expression vectors for the production of purified EEC, antibodies capable of binding specifically to EEC, hybridization probes or oligonucleotides for the detection of EEC-encoding nucleotide sequences, genetically engineered host cells for the expression of EEC, diagnostic tests for chemokine activation based on EEC-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
REFERENCES:
Abu-Ghazaleh et al., Immunol Ser 57:137-67 (1992)--only Abstracts available.
Capron, Mem Inst Oswaldo Cruz 87:83-9 (1992)--only Abstracts available.
Guyton, Textbook of Medical Physiology, WB Saunders Co., Philadelphia, PA (1991), pp. 365-384.
Isselbacher et al., Harrison's Principles of Internal Medicine, McGraw-Hill, New York City (1994), pp. 1437-1504.
Zucker-Franklin et al., Chapter 5, Eosinophils, Atlas of Blood Cells, Function and Pathology, Lea and Febiger, Philadelphia, PA (1988).
Schall, Chemotactic Cytokines: Targets for Therapeutic Development, International Business Communications, Southborough, MA, pp. 180-270 (1994).
Paul, Fundamental Immunology, Raven Press, New York City (1993), pp. 822-826.
Sommer et al, "Minimal homology requirements for PCR primers", Nucleic Acids Res. 17(16):6749, 1989.
Kwon et al, "A new chemokine, MMRP2", Genbank accession number U15209, Sep. 1994.
Bandman Olga
Coleman Roger
Stuart Susan G.
Billings Lucy J.
Fredman Jeffrey
Incyte Pharmaceuticals Inc.
Jones W. Gary
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