Chemokine binding protein and methods of use therefor

Details Chemokine binding protein and methods of use therefor Chemokine binding protein and methods of use therefor

1996-04-19

1998-11-10

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 530350, 424 84, C61K 3816, C07K 14065

Patent

active

058344195

ABSTRACT:
The present invention provides a method of use for a novel type I chemokine binding protein encoded by poxviruses and having amino acid sequence homology with the myxoma virus T7 interferon-.gamma. receptor homolog against disease syndromes associated with acute or chronic dysregulated inflammatory responses.

REFERENCES:
patent: 5464938 (1995-11-01), Smith et al.
Mossman et al., "Myxoma Virus M-T7, a Secreted Homolog of the Interferon-y Receptor, Is a Critical Virulence Factor for the Development of Hyxomatosis in European Rabbits", Virology, vol. 215, pp. 17-30, 1996.
McFadden et al., "Interruption of Cytokine Networks by Poxviruses: Lessons from Myxoma Virus", Journal of Leukocyte Biology, vol. 57, pp. 731-738, 1995.
Upton et al., "Encoding of a Homolog of the IFN-y Receptor by Myxoma Virus", Science, Nov. 20, 1992, vol. 258, pp. 1369-1372.
Mossman et al., "The Myxoma Virus-solube Interferon-y Receptor Homolog, M-T7, Inhibits Interferon-y in a Species-specific Manner", The Journal of Biological Chemistry, vol. 270, No.7, Issue of Feb. 17, pp. 3031, 3038, 1995.
Mossman et al., "Species Specificity of Ectromelia Virus and Vaccinia Virus Interferon-y Binding Proteins", Virology, vol. 208, pp. 762-769, 1995.
Neote et al 1993 (Cell 72, 415).
Chaudhuri et al 1994 (J. Biol. Chem. 269, 7835).
Ahuja et al. 1994 (Immunol. Today 15, 281).
Horuk et al 1994 (Trends Pharm. Sci. 15, 159).

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