Chemo-enzymatic process for the preparation of escitalopram

Details Chemo-enzymatic process for the preparation of escitalopram Chemo-enzymatic process for the preparation of escitalopram

2006-10-06

2008-12-30

Dentz, B. (Department: 1625)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

C435S128000, C549S467000

Reexamination Certificate

active

07470526

ABSTRACT:
A process for preparing an intermediate for synthesizing escitalopram and the pharmaceutically acceptable salts thereof from 4-(4-dimethylamino)-1-(4′-fluorophenyl)-1-(hydroxybutyl)-3-(acyloxymethyl)benzonitrile is described. The process involves converting said intermediate into the (S+) enantiomer of citalopram by means of enzymatic enantiomeric resolution.

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Solares et al.,Tetrahedron Assymetry, 15(2):341-345 (2004).

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