Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof
Patent
1998-02-10
1998-11-24
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus acids or salts thereof
562 25, C07F 906, C07F 902
Patent
active
058409637
ABSTRACT:
Novel methods and compositions which generate chemiluminescence are provided. The compositions comprise a heterocyclic enol phosphate compound and a dihydroxyaromatic compound in which the two hydroxy groups are separated by an even number of ring carbon atoms. Novel methods and compositions for generating chemiluminescence by reaction with a hydrolytic enzyme are provided as well. The compositions comprise a heterocyclic enol phosphate compound and a protected dihydroxyaromatic compound in which one of the hydroxy groups of the dihydroxyaromatic compound is protected with an enzyme-cleavable group. The novel chemiluminescent compositions are useful in methods for producing chemiluminescence for use in assays of hydrolytic enzymes and enzyme inhibitors and in assays employing labeled specific binding pairs.
REFERENCES:
Stillwell, W.: The possible role of quinol phosphates in the origin of photophosphorylation. Cellul. Chem. Technol. vol. 11, pp. 361-372; see Answer 1 of Caplus on p. 1, 1977.
Duenkheimer.: Biochemistry. vol. 3, pp. 1948 and 1952; see Answer 3 of Beilstein, 1964.
Aulakh Charanjit S.
Handley Richard S.
Lumigen Inc.
Rotman Alan L.
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