Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes

Details Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes

1997-06-30

2000-10-31

Tucker, Philip

Compositions

Chemiluminescent

549332, 435 4, 435 6, C09K 300, C07D30300

Patent

active

061397814

ABSTRACT:
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting pattern of the molecule results in a very high luminescent count, thus providing for a sensitive and precise assay for haptens, analytes, polynucleotides and the like. These substituted aryl-containing 1,2-dioxetane compounds can be used as direct labels in an immunoassay or when derivatized with an appropriate leaving group, can be used as a substrate for a enzyme immunoassay. The unusual chemiluminescence of the compounds allows the timing of the luminescent reaction to be exactly controlled.

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patent: 5538847 (1996-07-01), Bronstein et al.
patent: 5582980 (1996-12-01), Bronstein et al.
patent: 5851771 (1998-12-01), Bronstein et al.
Cowan et al., Elements of Organic Photochemistry, Plenum Press, Jul. 1978, pp. 122-124, 1978.

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