Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes

Details Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes

1992-10-30

1997-02-18

Tucker, Philip

Compositions

Chemiluminescent

549215, 549219, 549220, 549221, C09K 300, C07F 906

Patent

active

056038682

ABSTRACT:
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting pattern of the molecule results in a very high luminescent count, thus providing for a sensitive and precise assay for haptens, analytes, polynucleotides and the like. These substituted aryl-containing 1,2-dioxetane compounds can be used as direct labels in an immunoassay or when derivatized with an appropriate leaving group, can be used as a substrate for a enzyme immunoassay. The unusual chemiluminescence of the compounds allows the timing of the luminescent reaction to be exactly controlled.

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