Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase
Patent
1997-05-01
2000-11-07
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving oxidoreductase
435 6, 435 14, 435177, 435180, C12Q 128, C12Q 154
Patent
active
061435147
ABSTRACT:
Compositions, methods and kits are disclosed. The compositions comprise a matrix having incorporated therein a label capable of being modified by singlet oxygen. A catalyst capable of catalyzing the formation of singlet oxygen is bound to the matrix, which permits the diffusion of singlet oxygen therein. The compositions may be used in methods for detecting hydrogen peroxide or a compound capable of generating hydrogen peroxide. A sample suspected of containing such compound is combined with a composition in accordance with the present invention. The combination is subjected to conditions wherein such compound generates hydrogen peroxide. The reaction of singlet oxygen with the label is determined, the reaction thereof indicating the presence of the compound capable of generating hydrogen peroxide.
REFERENCES:
patent: 4233402 (1980-11-01), Maggio et al.
patent: 5084381 (1992-01-01), Akimoto et al.
patent: 5332662 (1994-07-01), Ullman
patent: 5532138 (1996-07-01), Singh et al.
patent: 5536834 (1996-07-01), Singh et al.
patent: 5556758 (1996-09-01), Allen
patent: 5578498 (1996-11-01), Singh et al.
patent: 5616719 (1997-04-01), Davalian et al.
patent: 5618732 (1997-04-01), Pease et al.
patent: 5709994 (1998-01-01), Pease et al.
O'Connell, et al.; A Highly Sensitive Immunoassay System Involving Antibody-Coated Tubes and Liposome-Entrapped Dye; Clin. Chem.; 31/9:1424-1426; 1985.
Ullman, et al.; Luminescent oxygen channeling assay (LOCI.TM.): sensitive, broadly applicable homogeneous immunoassay method; Clin. Chem.; 42/9:1518-1526; 1996.
Ullman, et al.; Luminescent oxygen channeling immunoassay: Measurement of particle binding kinetics by chemiluminescence; Proc. Natl. Acad. Sci. USA; 91:5426-5430; 1994.
McCapra, et al.; Luminescent Labels for Immunoassay-From Concept to Practice; Journal of Bioluminescence and Chemiluminescence; 4:51-58; 1989.
Seitz, Rudolf W.; Immunoassay Labels Based on Chemiluminescence and Bioluminescence; Clin. Biochemistry; 17:120-125; 1984.
Seliger, et al.; Chemiluminescence of Benzo[a]Pyrene-7,8-Diol; Photochem. Photobiol.; 36:359-365; 1982.
Lee, et al.; Chemiluminescence from the Reaction of Singlet Oxygen with 10,10'-Dimethyl-9,9'-biacridylidene. A Reactive 1,2-Dioxetane; J. Org. Chem.; 41 No. 16:2685-2688; 1976.
Grayeski, Mary Lynn; Chemi- and Bioluminescence; edited by John G. Burr; Marcel Dekker, Inc.; 16:469-493; 1985.
McCapra, F.; Potential applications of bioluminescence and chemiluminescence in biosensors; Biosensors Fundamentals and Applications; No. 31:617-637; 1987.
McCapra, F. et al.; Selected Chemical Reactions That Produce Light; Bioluminescence and Chemiluminescence; Instruments and Applications; 1:9-42.
Poulsen, J.R., et al.; Solid-State Peroxyoxalate Chemiluminescence Detection of Hydrogen Peroxide Generated in a Post-Column Reaction; J. Chromatography; 360 No. 2:371-383; Jun. 25, 1986.
Wasserman, H.; et al.; Singlet Oxygen; Academic Press; No. 12:597-641; 1979.
E. Ullman et al, Clinical Chemistry, vol. 42, No. 9, pp. 1518-1526, 1996.
Singh Sharat
Ullman Edwin F.
Ceperley Mary E.
Dade Behring Marburg GmbH
Gattari Patrick G
LandOfFree
Chemiluminescent compositions and their use in the detection of does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chemiluminescent compositions and their use in the detection of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemiluminescent compositions and their use in the detection of will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1639262