Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-07-08
2000-02-29
Campbell, Eggerton A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, C12Q 168, G01N 3353
Patent
active
060307730
ABSTRACT:
An assay for systemic lupus erythematosus based upon capture of the anti-dsDNA portion of IgG in a human serum specimen by the Fc part of a molecule using solid phase immobilized F(ab')2 fragment of anti-human IgG specific for Fc, the captured IgG being then incubated with a synthetic dsDNA tagged with a moiety from which a signal proportional to the quantity of said synthetic dsDNA can be elicited. Upon eliciting a signal from the moiety, the amount of antibody to dsDNA can be quantified, providing diagnostic and prognostic information regarding the disease.
REFERENCES:
patent: 4391904 (1983-07-01), Litman et al.
J. Lab.Clin. Med. 97:842-853 (1981) Pope. R.M. et al "IgG Rheumatoid factor: analysis . . . ".
J. Immunol. Methods 132:91-101 (1990) Emlem. W. et al. "A new ELISA for detection of ds-DNA . . . ".
Pollard-Knight, J. Meth Cell. Mol. Biol. 2:113-132 (1990) "Current methods in nonradioactive . . . ".
Pope et al., J. Lab. Clin. Med. 97:842-853 (1981) "IgG Rheumatoid factor: ".
Emlen et al., J. Immun. Meth. 132:91-101 (1990) "A new ELISA for the detection . . . ".
Campbell Eggerton A.
Schiller Robert J.
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