Chemiluminescent acridinium salts

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D21904

Patent

active

057836990

ABSTRACT:
Acridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a sulfonamide and acylating with an activated carboxylic acid of an acridine or isomer thereof. The N-sulfonyl-9-acridinium carboxamide and isomers may be conjugated to antigens, haptens, antibodies, and nucleic acids for use in chemiluminescent assays.

REFERENCES:
patent: 3431264 (1969-03-01), Sheehan et al.
patent: 3539574 (1970-11-01), Sheehan et al.
patent: 4338213 (1982-07-01), Tseng et al.
patent: 4697747 (1987-10-01), Lin
patent: 4745181 (1988-05-01), Law et al.
patent: 4946958 (1990-08-01), Campbell et al.
patent: 5283334 (1994-02-01), McCapra
patent: 5321136 (1994-06-01), McCapra
patent: 5338847 (1994-08-01), McCapra
patent: 5395752 (1995-03-01), Law et al.
patent: 5468646 (1995-11-01), Mattingly et al.
patent: 5521103 (1996-05-01), Zomer et al.
patent: 5543524 (1996-08-01), Mattingly
patent: 5545739 (1996-08-01), Mattiugly
patent: 5565570 (1996-10-01), Mattingly
patent: 5594112 (1997-01-01), Sato
patent: 5669819 (1997-09-01), Mattingly
F. McCapra, Chapter 9 entitled "Chemiluminescent Reactions of Acridines" in Chemistry of Heterocyclic Compounds, vol. 9:615-630 (1973).
R. Hart et al., "The Use of Acridinium Ester Labelled Streptavidin in Immunoassays", J. Immunol. Methods, 101:91-96 (1987).
Richardson, "Clinical Chemistry", 31(10):1664-1668, (1985).
Catherall et al., J. Chem. Soc. Faraday Trans. 2, 80:823-834 (1984).
Gill, Aldrichim ACTA, 16:59-61 (1983).
Kobayashi et al.,Anal. Chem., 52:424-427, (1980).
Kircka et al., "Diagnostic Medicine", 1: 45-52 (1984).
Miyaguchi et al., J. Chromatogr., 303: 173-176 (1984).
Schuster et al. Advances in Physical Organic Chemistry, 18: 187-238 (1984).
Weeks et al., Clin. Chem., 29/8: 1474-1479 (1983).
Mattingly J. Brochmin. Chemilumin vol. 6 No. 2 pp. 107-114 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chemiluminescent acridinium salts does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemiluminescent acridinium salts, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemiluminescent acridinium salts will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1648023

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.