Chemiluminescent acridinium compounds and analogues thereof...

Details Chemiluminescent acridinium compounds and analogues thereof... Chemiluminescent acridinium compounds and analogues thereof...

2006-08-29

2006-08-29

Gitomer, Ralph (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C546S102000

Reexamination Certificate

active

07097995

ABSTRACT:
A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows:in-line-formulae description="In-line Formulae" end="lead"?Lumi-M-PFormula Iin-line-formulae description="In-line Formulae" end="tail"?where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following:where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.

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