Chemiluminescent 1,2-dioxetanes

Details Chemiluminescent 1,2-dioxetanes Chemiluminescent 1,2-dioxetanes

1994-04-25

1996-12-10

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, 435810, 435975, 536 181, 536 2621, 536 2623, 536 267, 536 2626, 536 2713, 549330, 549332, C12Q 100, C12Q 168, G01N 3353, C07H 1524

Patent

active

055829805

ABSTRACT:
Spiroadamantyl dioxetanes bearing an alkoxy substituent, and a phenyl substituted on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a meta-substituted moiety designated OX, wherein the X is cleaved by an enzyme with which the dioxetane is permitted to come in contact with. The T.sub.1/2 kinetics of the chemiluminescent reaction, as well as the signal intensity and/or quantum yield of the chemiluminescent reaction, can be altered by addition of a chlorine substituent at position 4 on the phenyl ring. Signal strength can further be enhanced by recognized chemiluminescent enhancers.

REFERENCES:
patent: 4931223 (1990-06-01), Bronstein et al.
patent: 4952707 (1990-08-01), Edwards et al.
patent: 4983779 (1991-01-01), Schaap
patent: 5132204 (1992-07-01), Urdea et al.
patent: 5145772 (1992-09-01), Voyta et al.
patent: 5326882 (1994-07-01), Bronstein et al.
Chemical Abstract, vol. 117, AN 107794, WO 92/04341, Mar. 19, 1992.

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