Chemically specific patterning on solid surfaces using surface i

Details Chemically specific patterning on solid surfaces using surface i Chemically specific patterning on solid surfaces using surface i

1997-04-08

1999-12-14

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435174, 435176, 435177, 435180, C12P 100, C12N 1114, C12N 1102, C12N 1108

Patent

active

06001587&

ABSTRACT:
An immobilized substrate surface is chemically modified by manipulating an nzyme which is immobilized to a solid surface. Modifications include (1) chemical dissection of a substrate surface such as by chemical hydrolysis, (2) chemical synthesis on a substrate surface, and (3) chemical patterning of a substrate surface. The enzyme may be coupled to colloidal beads or particles, locally flat solid surfaces including planar, textured planar, cylindrical and spherical surfaces or arbitrary predefined shapes, or scanning probe microscope probes. In the patterning applications, colloidal particles containing the enzyme can be confined to desired regions of the substrate surface by various techniques which control the movement of the particles. The particles can be confined to tunnels or channels in a patterned polymer mold on top of the substrate surface. The enzyme can also be immobilized onto the surface of a raised pattern and this patterned surface can then be placed in contact with the immobilized substrate.

REFERENCES:
patent: 5470739 (1995-11-01), Akaike et al.
patent: 5602029 (1997-02-01), Miyamoto
A. Ashkin et al, Nature, 330, 769-771 (1987).
R. Singhvi et al, Science, 264, 696-698 (1994).
D. Turner et al, Langmuir, 12, 4411-4416 (1996).
T. E. Wilson et al, Langmuir, 10, 1512-1516 (1994).
H. Hagestam et al, J. of Chromatography, 351, 239-248 (1986).
H. Hagestam et al, Anal. Chem., 57, 1757-1763 (1985).
J. K. Whitesell et al, Angew. Chem. Int. Ed. Engl., 33, 871-873 1994.

Affiliated with

Also associated with

Rating

Chemically specific patterning on solid surfaces using surface i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemically specific patterning on solid surfaces using surface i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemically specific patterning on solid surfaces using surface i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-862045