Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1987-06-18
1988-12-13
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
424 92, 530397, 530406, 530410, 514 21, C07K 1500, C07K 1706, A61K 3736
Patent
active
047911921
ABSTRACT:
The chemically modified protein of the present invention has a strong islet-activating activity and is lower in various side effects than non-modified IAP, so that it may be employed as a prevention and therapeutic drug for diabetes.
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Motoyuki Yajima et al., "Islets-Activating Protein (IAP in Bordetella pertussis that Potentiates Insulin Secretory Responses of Rate", J. Biochem., vol. 83, pp. 295-303 (1978).
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Katsumi Nogimori et al., "Chemical Modification of Islet-Activating Protein, Pertussis Toxin Essential Role of Free Amino Groups in Its Lymphocytosis-Promoting Activity", Biochimia et Biophysica Acta, vol. 801, pp. 220-231 (1984).
Ayako Matsushima et al., "Modification of E. coli Asparaginase with 2,4-Bis(O-Methoxypolyethylene Glycol)-6-Chloro-S-Triazine (Activated PEG.sub.2); Disappearance of Binding Ability Towards Anti-Serum and Retention of Enzymic Activity", Chemistry Letters, pp. 773-776 (1980).
Japanese Unexamined Patent Laid Open No. 129296/1980.
Ito Takashi
Nakagawa Yasushi
Schain Howard E.
Takeda Chemical Industries Ltd.
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