Chemically modified nucleic acids and methods for coupling nucle

Details Chemically modified nucleic acids and methods for coupling nucle Chemically modified nucleic acids and methods for coupling nucle

1998-05-04

2000-04-11

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 266, 436524, C12Q 168

Patent

active

060486953

ABSTRACT:
The invention relates to novel chemically modified nucleic acids with enhanced lability towards solid supports, such as glass. These modified nucleic acids can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified nucleic acids as well as methods for preparing these microarrays are also useful.

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