Chemically modified enzymes with multiple charged variants

Details Chemically modified enzymes with multiple charged variants Chemically modified enzymes with multiple charged variants

2008-05-13

2008-05-13

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S221000, C510S392000, C536S023200

Reexamination Certificate

active

10993827

ABSTRACT:
This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain comprising a multiply charged moiety. The enzymes show improved interaction and/or specificity and/or activity with charged substrates.

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