Chemically modified endotoxin immunizing agent

Details Chemically modified endotoxin immunizing agent Chemically modified endotoxin immunizing agent

1977-06-17

1980-01-22

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424 94, 424180, 536 1, 536 18, 536119, 260112R, A61K 3173, C07H 506, C08B 3700

Patent

active

041850904

ABSTRACT:
A bacterial endotoxin lipopolysaccharide of reduced toxicity covalently coupled to a protein antigen exhibits enhanced adjuvant effects. The coupling was affected by reaction with haloacylhalide. Lipopolysaccharide acylated with an anhydride of a dibasic acid is detoxified; in combination with endotoxin polysaccharide covalently coupled to protein antigen it developed synergistic immunogenic effects.

REFERENCES:
patent: 3600378 (1971-08-01), Marsh et al.
McIntire et al., Biochemistry, vol. 6, No. 8, pp. 2363-2372, Aug. 1967.

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