Chemically fixed micelles

Details Chemically fixed micelles Chemically fixed micelles

1993-10-18

1995-07-04

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424426, 424450, 525901, 525937, 525938, 525941, 5147721, A61K 4734, A61K 9133, C08G 8100

Patent

active

054298261

ABSTRACT:
There is provided copolymer particles wherein the particles are derived from chemically fixed micelles that comprise a copolymer. The copolymer is an amphiphilic block or graft copolymer comprising a water soluble component and an oleophilic component that can be crosslinked in an aqueous environment; and the oleophilic component is crosslinked. The particles can be dispersed in an aqueous continuous phase. The particles can contain other materials associated with the oleophilic component such as biochemical agents or other materials such as photographic materials such as couplers and dyes.

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patent: 5078994 (1992-01-01), Nair et al.
patent: 5145518 (1992-09-01), Winnik et al.
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"New Macromolecular Carriers For Drugs. I. Preparation and Characterization of Poly (oxyethylene-b-isoprene-b-oxyethylene) Block Copolymer Aggregates" by A. Rolland et al, Journal of Applied Polymer Science, Mar. 5, vol. 7, 44(1992) pp. 1195-1203.
"Photochemical Stabilization of Block Copolymer Micelles" by D. J. Wilson and G. Riess, European Polymer Journal, vol. 24, No. 7, pp. 617-621.
Park et al, Synthesis of Microphased Core-Corona Type Microgel, Polymer Communications, vol. 29 pp. 230-231 (1988).
Ishizu and Fukutomi, Core-Shell Type Polymer Microspheres Prepared from Block Copolymers, J. Polymer Sci., Part C: Polymer Letters, vol. 26, 281-286 (1988).

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