Chemically defined polymeric carriers for release of covalently

Details Chemically defined polymeric carriers for release of covalently Chemically defined polymeric carriers for release of covalently

1993-06-03

1996-08-27

Wu, Shean

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to cyclopentano-hydrophenanthrene ; derivative thereof

424153, 424 169, 424 9341, 530333, 530337, 530300, A61K 5108, A61K 4900, C07K 100, C07K 200

Patent

active

055498833

ABSTRACT:
A chemically defined polymeric carrier comprising a series of .alpha.-amino acids in any combination containing side chains to which diagnostic/therapeutic and chelating agents can be covalently joined through cleavable linkers either directly or covalently joined through cleavable linkers after chemical modification of the side chains. Hydrazone, disulfide, and ester linkages in any combination can be present in the polymeric carrier between the side chains of the .alpha.-amino acids and the agents. The presence of a particular covalent linkage between the side chain and the agent in the carrier is determined by the functional group present in the side chain of the .alpha.-amino acid and the functional group present in the agent. The .alpha.-amino acids with side chains to which agents do not covalently join can function as spacers to minimize interaction between bulky molecules attached to the polymeric carrier. In addition, those .alpha.-amino acids with charged or hydrophilic side chains to which agents do not covalently join can provide increased solubility to the polymeric carrier.

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