Chemically-defined non-polymeric valency platform molecules and

Details Chemically-defined non-polymeric valency platform molecules and Chemically-defined non-polymeric valency platform molecules and

1995-05-30

1997-02-25

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1904, A61K 3170

Patent

active

056060475

ABSTRACT:
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.

REFERENCES:
patent: 4191668 (1980-03-01), Katz
patent: 4220565 (1980-09-01), Katz
patent: 4650675 (1987-03-01), Borel et al.
patent: 4751181 (1988-06-01), Keene
patent: 5126131 (1992-06-01), Dintzis et al.
patent: 5162515 (1992-11-01), Conrad et al.
patent: 5276013 (1994-01-01), Conrad et al.
Borel et al., "Prevention of murine lupus nephritis by carrier-dependent induction of immunologic tolerance to denatured DNA" Science (1973) 182:76-78.
Parker et al., "Modification of NZB/NZW F.sub.1 autoimmune disease by development of tolerance to DNA" J. Immunol. (1974) 113(1):292-297.
Borel et al., "A possible new therapy of systemic lupus erythematosus (SLE)" Ann. N.Y. Acad. Sci. (1986) 475:296-306.
Borel et al., "Oligonucleotide linked to human gammaglobulin specifically diminishes anti-DNA antibody formation in cultured lymphoid cells from patients with systemic lupus erythematosus" J. Clin. Invest. (1988) 82: 1901-1907.
Sasaki et al., "Induction of immunological tolerance to single-stranded and double-stranded DNA" Scand. J. Immunol. (1982) 16:191-200.
Sehon, "Suppresion of IgE antibody responses with tolerogenic conjugates of allergens and haptens" Prog. Allergy (1982) 32:161-202.
Wilkinson et al., "Tolerance induction in mice by conjugates of monoclonal immunoglobulins and monomethoxypolyethylene glycol" J. Immunol. (1987) 139:326-331.
Borel et al., "A novel technique to link either proteins or peptides to gammaglobulin to construct tolerogens" J. Immunol. Methods (1990) 126:159-168.
Eshhar et al., "Induction of tolerance to nucleic acid determinants by administration of a complex of nucleoside D-glutamic acid and D-lysine (D-GL)" J. Immunol. (1975) 144(2):872-876.
Papalian et al., "Reaction of systemic lupus erythematosus antinative DNA antibodies with native DNA fragments from 20 to 1,200 base pairs" J. Clin. Invest. (1980) 65:469-477.
Stollar et al., "Secondary structure in denatured DNA is responsible for its reaction with antinative DNA antibodies of systematic lupus erythematosus sera" (1980) 66:210-219.
Agrawal et al., "Efficient methods for attaching non-radioactive labels to the 5' end of synthetic oligonucleotides" Nucl. Acids Res. (1987) 14(15):6227-6245.
Kremsky et al., "Immobilization of DNA via oligonucleotides containing an aldehyde or carboxylic acid group at the 5' terminus" Nucl. Acids Res. (1987) 15(7):2891-2909.

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