Chemical treatment, without detergents or enzymes, of tissue to

Details Chemical treatment, without detergents or enzymes, of tissue to Chemical treatment, without detergents or enzymes, of tissue to

1997-05-08

1999-11-30

Saucier, Sandra E.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

435 11, 424422, 623 2, 623 11, A61F 224, A61F 202, A01N 102

Patent

active

059938447

ABSTRACT:
The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

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patent: 5460962 (1995-10-01), Kemp
patent: 5523291 (1996-06-01), Janzen et al.
Courtman et al., J. of Biomedical Research, 28:655-666 (1994).
Wilson, G.J., et al., Ann. Thorac. Surg., 60:5353-5358 (1995).
Bodnar, E., et al., Thorac. Cardiovascular Surg., 34:82-85 (1986).

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