Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving glucose or galactose
Patent
1996-09-03
1998-02-17
Gitomer, Ralph
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving glucose or galactose
435 692, 422 57, 436170, C12Q 154, C12Q 128, G01N 2100
Patent
active
057190348
ABSTRACT:
A chemical timer for a direct-reading reagent test strip changes color a predetermined time after a biological fluid is applied to the strip. The strip measures the concentration of an analyte in the fluid. The timer is a dry coating of an indicator, an enzyme-containing reagent that when hydrated can react with glucose to change the color of the indicator, an inhibitor to inhibit the change in color of the indicator, glucose, and optionally, an aldose that does not react with the enzyme in the reagent. Preferably, the reagent and glucose are present in excess in the coating, and the time it takes for the timer color to change can be controlled by the inhibitor concentration. The aldose provides timer stability, probably by interfering with glycosylation by the glucose in the dry state.
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Authors: Rodric H. White-Stevens and Lon R. Stover Title: Interference by Ascorbic Acid in Test Systems Involving Peroxidase II. Redox-Coupled Indicator Systems Publication: Clinical Chemistry, vol. 28, No. 4, 1982, pp. 589-595.
Reaction of Monosaccharides with Proteins: Possible Evolutionary Significance. Science, vol. 213, 10 Jul. 1981.
Kiser Ernest J.
Rice Edward G.
Tomasco Michael F.
Yu Yeung S.
Gitomer Ralph
Lifescan Inc.
Riesenfeld James
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