Chemical synthesis of reagents for peptide coupling

Details Chemical synthesis of reagents for peptide coupling Chemical synthesis of reagents for peptide coupling

2008-01-08

2008-01-08

Barts, Samuel A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Boron containing

C564S123000, C530S402000

Reexamination Certificate

active

11229926

ABSTRACT:
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

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