Chemical synthesis of reagents for peptide coupling

Organic compounds -- part of the class 532-570 series – Organic compounds – Boron containing

Reexamination Certificate

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C564S123000, C530S402000

Reexamination Certificate

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11229926

ABSTRACT:
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

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