Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1999-09-08
2000-10-10
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544106, 544107, 544173, C07D26530, C07D26532
Patent
active
061303313
ABSTRACT:
The present invention relates to a process for the preparation of substantially pure N-((S)-(-)-.alpha.-methylbenzyl)-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one hydrochloride, which comprises selectively crystallising the (S,S)-diastereomer as the hydrochloride salt from a mixture of the (S,R)- and (S,S)-diastereomers in an organic solvent, and collecting the resultant crystalline product.
REFERENCES:
patent: 6046325 (2000-04-01), Ashwood et al.
Ashwood Michael Stewart
Bishops Brian Christopher
Cottrell Ian Frank
Edwards John Simon
Merck Sharp & Dohme Ltd.
Rose David L.
Schroeder Ben
Shah Mukund J.
Thies J. Eric
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