Chemical synthesis of 1,4-oxazin-2-ones

Details Chemical synthesis of 1,4-oxazin-2-ones Chemical synthesis of 1,4-oxazin-2-ones

1999-09-08

2000-04-04

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D26532

Patent

active

060463252

ABSTRACT:
The present invention relates to a process for the preparation of a compound of formula (I): ##STR1## wherein R.sup.1 is a C.sub.1-6 alkyl or arylC.sub.1-4 alkyl group; and R.sup.2 is a hydrogen atom, a halogen atom, or a group selected from C.sub.1-6 alkyl, CF.sub.3 or C.sub.1-6 alkoxy substituted by C.sub.1-4 alkoxy; which comprises reacting an anhydrous or hydrated glyoxal of formula (II) with a compound of formula (III): ##STR2## in the presence of an acid.

REFERENCES:
patent: 5668280 (1997-09-01), Alabaster et al.
patent: 5719147 (1998-02-01), Dorn et al.
Agami, et al., Tetrahedron Lett., 34, 7061 (1993).
Evans, et al., J. Am. Chem. Soc., 112, 4011-4030 (1990).

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