Chemical structure-insensitive method and apparatus for...

Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C250S281000, C250S282000, C250S293000

Reexamination Certificate

active

07842918

ABSTRACT:
In a method for exciting a precursor ion in an ion trap, the ion is trapped in a nonlinear trapping field that includes a quadrupolar field and a multipole field. The quadrupolar field is generated by applying a radio-frequency (RF) trapping voltage to the ion trap at a trapping amplitude and trapping frequency. A supplemental alternating-current (AC) voltage is applied to the ion trap at a supplemental amplitude and supplemental frequency. The supplemental amplitude is low enough to prevent ejection of the ion from the ion trap, and the supplemental frequency differs from the secular frequency of the ion by an offset amount. One or more operating parameters of the ion trap are adjusted, such that the ion absorbs energy from the supplemental field sufficient to undergo collision-induced dissociation (CID) without being in resonance with the supplemental field.

REFERENCES:
patent: 4736101 (1988-04-01), Syka et al.
patent: 5198665 (1993-03-01), Wells
patent: 5291017 (1994-03-01), Wang et al.
patent: 5300772 (1994-04-01), Buttrill, Jr.
patent: 5302826 (1994-04-01), Wells
patent: 5451782 (1995-09-01), Kelley
patent: 5521380 (1996-05-01), Wells et al.
patent: 5714755 (1998-02-01), Wells et al.
patent: 5793038 (1998-08-01), Buttrill, Jr.
patent: 5864136 (1999-01-01), Kelley et al.
patent: 6087658 (2000-07-01), Kawato
patent: 6124591 (2000-09-01), Schwartz et al.
patent: 6410913 (2002-06-01), Brekenfeld et al.
patent: 6617585 (2003-09-01), Stickel
patent: 6710336 (2004-03-01), Wells
patent: 6831275 (2004-12-01), Franzen et al.
patent: 6897438 (2005-05-01), Soudakov et al.
patent: 7034293 (2006-04-01), Wells
patent: 7141789 (2006-11-01), Douglas et al.
patent: 2004/0051036 (2004-03-01), Franzen et al.
patent: 2004/0159785 (2004-08-01), Kato
patent: 2005/0061966 (2005-03-01), Ding et al.
patent: 2006/0169884 (2006-08-01), Syka
patent: 2007/0075239 (2007-04-01), Ding et al.
patent: 2007/0084994 (2007-04-01), Wang et al.
patent: 2007/0176096 (2007-08-01), Wells
patent: WO 2006/047889 (2006-05-01), None
Qin et al., “Matrix-Assisted Laser Desorption Iion Trap Mass Spectrometry: Efficient Isolation and Effective Fragmentation of Peptide Ions”, Anal. Chem., vol. 68, pp. 2108-2112 (1996).
Mirgorodskaya et al., “A General Method for Precalculation of Parameters for Sustained Off Resonance Irradiation/Collision-Induced Dissociation”, American Society for Mass Spectrometry, Published Online Feb. 13, 2002.
Collings et al., “Resonant Excitation in a Low-Pressure Linear Ion Trap”, American Society for Mass Spectrometry, Published Online May 2, 2003.
Michaud et al., “Ion Excitation in a Linear Quadrupole Ion Trap with an Added Octopole Field”, American Society for Mass Spectrometry, Published Online May 3, 2005.
Collings, B. A., “Increased Fragmentation Efficiency of Ions in a Low Pressure Linear Ion Trap with an Added dc Octopole Field”, American Society for Mass Spectrometry, Published Online Jun. 24, 2005.
Konenkov et al., “Linear Quadrupoles with Added Hexapole Fields”, American Society for Mass Spectrometry, Published Online Jun. 5, 2006.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chemical structure-insensitive method and apparatus for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical structure-insensitive method and apparatus for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical structure-insensitive method and apparatus for... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4239941

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.