Fluent material handling – with receiver or receiver coacting mea – With conveying means to supply successive receivers – Sampler type
Patent
1998-09-03
2000-07-04
Noland, Thomas P.
Fluent material handling, with receiver or receiver coacting mea
With conveying means to supply successive receivers
Sampler type
422 63, G01N 3510
Patent
active
060824174
ABSTRACT:
This invention is directed to a cassette chemical immobilization and treatment system and method for enabling the performance of various complex chemistries with minimal human intervention, near-zero dead volume, and flow-through protocols pursuant to a predetermined instruction set encoded on a multiple-address chemical treatment cassette assembly. The cassette assembly comprises a plurality of analyte sample columns ("mini-columns"), reagent wells containeing pre-packaged reagents including powdered, micoencapsulated, liquid or lyophillized reagents, analyte loading funnels, alignment means for the analyte sample columns, and a machine readable instruction code set for identifying a chemical treatment protocol. The mini-columns are improved columns having high pressure interface capability to permit direct insertion of the mini-column into a high-pressure solvent line for use as a support column for HPLC analysis. A sample loader loads analyte samples either singly or simultaneously into the multiple, addressable mini-columns without the need to load the sample funnel/column assembly into a separate reaction chamber. The chemical treatment station (CTS) of this invention reads the machine readable instruction code and performs chemistries on the analyte, including mixing solvents, reactants and buffers; detaching and shuttling the analyte back and forth (i.e., pump-up and pump-down); performing complex chemistries either on or off-column; salvation of powdered or lyophillized reagents; and performing in-line, on-board analysis. These protocols are performed automatically pursuant to instructions contained on a bar code, and are performed without having to remove the cassette from the CTS, without having to detach and reattach a CTS/cassette interface, or otherwise require human intervention. Further, the same chemistries may be performed on all sample mini-column addresses, or a separate completely independent set of protocols may be defined for each address, or for each block of addresses pursuant to the instructions contained in the machine readable code on the cassette.
REFERENCES:
patent: 3518164 (1970-06-01), Andelin et al.
patent: 3559454 (1971-02-01), Evans
patent: 4096825 (1978-06-01), Golias et al.
patent: 4929426 (1990-05-01), Bodai et al.
patent: 4932081 (1990-06-01), Burns
patent: 5374395 (1994-12-01), Robinson et al.
patent: 5578268 (1996-11-01), Champseix et al.
patent: 5589063 (1996-12-01), Sanford et al.
patent: 5602037 (1997-02-01), Ostagaard et al.
patent: 5697409 (1997-12-01), Bishop et al.
patent: 5762873 (1998-06-01), Fanning et al.
Noland Thomas P.
Protigal Stanley N.
Sabath Robert P.
LandOfFree
Chemical sample loading station for loading sample solutions in does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chemical sample loading station for loading sample solutions in , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical sample loading station for loading sample solutions in will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1477231