Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2004-05-26
2010-02-23
Lam, Ann Y (Department: 1641)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
Reexamination Certificate
active
07666662
ABSTRACT:
A chemical reaction device is provided for a chemical reaction between molecules immobilized on a solid phase and molecules in a solution, and a chemical analysis device is also provided to capture molecules in the solution by molecules immobilized on the solid phase through a chemical reaction and subsequent measurement of the captured molecules. Reaction efficiency as well as sample throughput are thereby improved. The chemical reaction device and the chemical analysis device use a channel of a microfluidic device for a reaction vessel, and at least a particular molecule is immobilized on an interior surface and a fixed structure or a non-fixed obstacle against a flow is provided in the channel. In a typical reaction vessel having an enzyme immobilized on an interior surface of a capillary and glass beads functioning as an obstacle for the flow filled in the channel of the capillary, a reaction solution can move either in one direction or back and forth in two directions to thereby undergo a reaction with the enzyme immobilized on the interior surface. The flow of the reaction solution is not a laminar flow so that a reaction between the particular molecule immobilized and the reaction solution proceeds at high efficiency.
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Kohara Yoshinobu
Noda Hideyuki
Okano Kazunori
A. Marquez, Esq. Juan Carlos
Hitachi , Ltd.
Lam Ann Y
Stites & Harbison PLLC
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