Chemical product usable as a non-radioactive carrier

Details Chemical product usable as a non-radioactive carrier Chemical product usable as a non-radioactive carrier

1986-12-29

1991-12-31

Maples, John S.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530382, 530388, 530391, 530399, 530409, C07K 1700, A61K 3724

Patent

active

050773895

ABSTRACT:
The present invention relates to a chemical product usable as a non-radioactive carrier which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneimine linkage (--CH.dbd.N--) or a methyleneamine linkage (--CH.sub.2 NH--) between a formyl group in the polyformy compound and an amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneimine linkage or a methyleneamine linkage between a formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction.

REFERENCES:
patent: 4287362 (1981-09-01), Yokoyama et al.
patent: 4338248 (1982-07-01), Yokoyama et al.
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4407871 (1983-10-01), Eisfeller
patent: 4425319 (1984-01-01), Yokoyama et al.
patent: 4440739 (1984-04-01), Azuma et al.
patent: 4474984 (1984-10-01), Ueda et al.
patent: 4564472 (1986-01-01), Ueda et al.
patent: 4666697 (1987-05-01), Takahashi et al.

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