Chemical product usable as a non-radioactive carrier

Details Chemical product usable as a non-radioactive carrier Chemical product usable as a non-radioactive carrier

1994-03-22

1995-01-24

Stoll, Robert L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 51, 536 45, 526315, 562556, 564153, C08B 3100, C08B 3702, C08F 1634, C07C31702, C07C23300

Patent

active

053844017

ABSTRACT:
A radioactive diagnostic agent which comprises (1) the unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound with intervention of a methyleneimine linkage (--CH.dbd.N--) or a methyleneamine linkage (--CH.sub.2 NH--) formed by the condensation between the formyl group in the polyformyl compound and the amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound with intervention of a methyleneimine linkage or a methyleneamine linkage formed by the condensation between the formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction, and (4) at least two radioactive metallic elements of which each is bonded to the chelating compound through a chelating bond.

REFERENCES:
patent: 4002730 (1977-01-01), Hartman et al.
patent: 4287362 (1981-09-01), Yokoyama et al.
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4425319 (1984-01-01), Yokoyama et al.
patent: 4460560 (1984-07-01), Tokes et al.
patent: 4564472 (1986-01-01), Ueda et al.
Krejcarek et al., Biochem. & Biophys. Res. Comm., vol. 77, No. 2 (1977) pp. 581-585.
Leung et al., Int. J. Appl. Radiation & Isotopes, vol. 29 (1978) pp. 687-692.
Schulz et al., Makromol. Chem., vol. 24, (1957), pp. 141-151.

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