Chemical process for the production of sulfonyl benzoic acids

Details Chemical process for the production of sulfonyl benzoic acids Chemical process for the production of sulfonyl benzoic acids

1996-11-18

1998-07-21

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562422, C07C 5116

Patent

active

057837295

ABSTRACT:
A process for preparing a compound of formula (I), ##STR1## where R.sup.1 is optionally substituted alkyl or phenyl, R.sup.2 is COOH, and R.sup.3 and R.sup.4 are independently selected from hydrogen, halo, haloalkyl, nitro, hydroxy, alkoxy, haloalkoxy or alkoxyalkoxy; which process comprises oxidising a compound of formula (II) ##STR2## where R.sup.1, R.sup.3 and R.sup.4 are as defined in relation to formula (I) and R.sup.5 is H, halo or C.sub.1-4 alkyl with sodium hypochlorite or sodium chlorite in the presence of a catalytic amount of a ruthenium or palladium compound and a phase transfer catalyst in an organic solvent at a pH of 7-11.

REFERENCES:
patent: 3504022 (1970-03-01), Bresson
patent: 3692828 (1972-09-01), Onopchenko
patent: 3812159 (1974-05-01), Lubowitz
patent: 3878240 (1975-04-01), Kuenzy
patent: 4503245 (1985-03-01), Giacobbe
patent: 4695673 (1987-09-01), Heather et al.
patent: 4780127 (1988-10-01), Michaely et al.
patent: 4914231 (1990-04-01), Manami
patent: 4954165 (1990-09-01), Baba
patent: 4965406 (1990-10-01), Dakka
patent: 4990659 (1991-02-01), Jihad
patent: 5087724 (1992-02-01), Tanaka
patent: 5155258 (1992-10-01), Kamiya
patent: 5175351 (1992-12-01), Rohrscheid
Journal of Medicinal Chemistry, vol. 17, No. 9, Sep. 1974, pp. 933-930, B.F. Cain et al: Potential Antitumor Agents. 14. Acridylmethanesulfonanilides.
Journal of Organic Chemistry, vol. 51, No. 15, Jul. 25, 1986, pp. 2880-2883, Y. Sasson et al.: Liquid-Phase Oxidation of Deactivated Methylbenzenes by Aqueous Sodium Hypochloride Catalyzed by Ruthenium Salts under Phase-Transfer Catalytic Conditions.

Affiliated with

Also associated with

Rating

Chemical process for the production of sulfonyl benzoic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical process for the production of sulfonyl benzoic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical process for the production of sulfonyl benzoic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1648273