Chemical process for the production of .alpha.-aminophosphonic a

Details Chemical process for the production of .alpha.-aminophosphonic a Chemical process for the production of .alpha.-aminophosphonic a

1979-10-01

1982-05-25

Hazel, Blondel

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2605025, 260970, 260985, C07C10352, C07C 902, C07G 700

Patent

active

043315917

ABSTRACT:
The present invention provides a process for the production of physiologically-useful .alpha.-aminophosphonic acids and peptide derivatives of the formula: ##STR1## wherein R and R.sub.1 may be the same or different and each can be hydrogen, deuterium or an optionally substituted lower alkyl group, lower alkenyl, lower alkynyl, cycloalkyl, aryl or heterocyclic radical containing one or more oxygen, nitrogen or sulphur atoms and which may be fused to an aromatic ring, a lower alkyl group substituted by a cycloalkyl radical, a lower alkyl group substituted by an aryl radical, a lower alkyl group substituted by a heterocyclic radical as defined above or R and R.sub.1 together form a polymethylene chain optionally interrupted by an oxygen, nitrogen or sulphur atom, or R.sub.1 represents, together with the C(R)--N< residue to which it is attached, the atoms required to complete a heterocyclic radical; and

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patent: 4028403 (1977-06-01), Sanderson
Kosolapoff, G., Organophosphorus Compounds, p. 137, New York, John Wiley and Sons, Inc.
Kosolapoff and Maier, Organic Phosphorus Compounds, New York, John Wiley and Sons.
Hickinbottom, W., Reaction of Organic Compounds, John Wiley and Sons, Inc., N.Y. 3rd Ed., pp. 420-432 (1962).

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