Chemical process for the preparation of 4-(6.sup.1 -methoxy-2.su

Details Chemical process for the preparation of 4-(6.sup.1 -methoxy-2.su Chemical process for the preparation of 4-(6.sup.1 -methoxy-2.su

1979-10-11

1981-05-26

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

560 53, C07C 4565, C07C 67313

Patent

active

042700043

ABSTRACT:
The present invention relates to a process for the preparation of 4-(6.sup.1 -methoxy-2.sup.1 -naphthyl)butan-2-one and to certain compounds for use in that process.
British patent specification No. 1,474,377 discloses inter alia that 4-(6.sup.1 -methoxy-2.sup.1 -naphthyl)butan-2-one possesses useful anti-inflammatory activity. A particularly favored process has now been discovered that can be used to produce 4-(6.sup.1 -methoxy-2.sup.1 -naphthyl)butan-2-one in particularly good yield.
The present invention provides a process for the preparation of 4-(6.sup.1 -methoxy-2.sup.1 -naphthyl)butan-2-one which process comprises the hydrogenation of a compound of the formula (I): ##STR1## wherein Ar is a 6-methoxy-2-naphthyl group; X and Y are each hydrogen atoms or together represent a second bond between the carbon atoms to which they are attached; and R is a group such that --CO.sub.2 R represents an ester group convertible by hydrogenation to a CO.sub.2 H group.

REFERENCES:
patent: 3917718 (1975-11-01), Collins
patent: 4029713 (1977-06-01), Parker
Bowman, J. Chem. Soc., 1950, pp. 323-329.
Jones, Organic Reactions, vol. 15, pp. 249-253, (1967).

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