Chemical process for preparing antibiotic L 17932 (deglucoteicop

Details Chemical process for preparing antibiotic L 17932 (deglucoteicop Chemical process for preparing antibiotic L 17932 (deglucoteicop

1995-05-30

1997-01-14

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530322, 530345, C07K 764

Patent

active

055941028

ABSTRACT:
The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acid hydrolysis in the presence of an organic aprotic solvent, and a purification thereof.

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Zanol, M., Cometti, A., Borghi, A., Lancini, G. C., "Isolation and Structure Determination of Minor Components of Teicompanin", (1988), Chromatographia, vol. 26, pp. 234-236.
McGahren et al., The Journal of Antibiotics, vol. 36, No. 12, pp. 1671-1682 (1983).
Bardone et al., The Journal of Antibiotics, vol. 31, No. 3, pp. 170-177 (1978).
Ellestad et al., The Journal of Antibiotics, vol. 36, No. 12 pp. 1683-1690 (1983).
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