Chemical process for manufacturing trifluoroacetaldehyde hydrate

Details Chemical process for manufacturing trifluoroacetaldehyde hydrate Chemical process for manufacturing trifluoroacetaldehyde hydrate

1992-05-20

1993-09-28

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568490, C07C 4541, C07C 4500

Patent

active

052488322

ABSTRACT:
A process for the manufacture of trifluoroacetaldehyde, or a hydrate or hemiacetal thereof, which comprises reduction of an ester of trifluoroacetic acid with a borohydride reducing agent in a hydroxylic solvent to form trifluoroacetaldehyde hydrate or hemiacetal; whereafter if the free aldehyde is required, water or alcohol is removed from the hydrate or hemiacetal respectively using conventional procedures.

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patent: 4211727 (1980-07-01), Entwistle et al.
patent: 4579976 (1984-04-01), Cheminal et al.
Hill et al., "Reprint from J. Organic Chemistry" vol. 32, Aug. 1967 pp. 2595-2600.
M. Braid, et al., "An Improved Synthesis of Perfluoroaldehydes" J. Amer. Chem. Soc. (1954) 76, 4027.
O. R. Pierce, et al., "A New Synthesis of Perfluoroaldehydes" J. Amer. Chem. Soc. (1954) 76, 300.
A. Thenappan, et al., "Reduction-Olefination of Esters: A New and Efficient Synthesis of a-Fluoro a,B-Unsaturated Esters" J. Org. Chem. (1990) 55, 4639-4642.
D. R. Husted, et al., "The Chemistry of the Perfluoro Acids and Their Derivatives. III. The Perfluoro Adlehydes" J. Amer. Chem. Soc. (1952) 74, 5422-5426.
Chemical Abstracts, (1981) 94, 156316j.

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